Molecular Regulation of Phosphate Metabolism by Fibroblast Growth Factor-23–Klotho System

Fibroblast Growth Factor 23 (FGF23) and Disorders of Phosphate Metabolism

Derangements in serum phosphate level result in rickets/osteomalacia or ectopic calcification indicating that healthy people without these abnormalities maintain serum phosphate within certain ranges. These results indicate that there must be a regulatory mechanism of serum phosphate level. Fibroblast growth factor 23 (FGF23) was identified as the last member of FGF family. FGF23 is produced by...

Regulation of protein metabolism and DNA synthesis by fibroblast growth factor in BHK-21 cells.

1. Acidic and basic fibroblast growth factors (aFGF, bFGF) were shown to inhibit protein breakdown in BHK-21 cells, with the latter exhibiting approx. 6-fold greater sensitivity. 2. The maximum response achieved was less than observed with insulin or insulin-like growth factor-1 (IGF-1), and was not additive with those growth factors over the 4 h measurement period. The inhibition of protein br...

Fibroblast Growth Factor 2 Direct Regulation of Rrna Transcription By

Direct regulation of rRNA transcription by fibroblast growth factor 2.

Fibroblast growth factor 2 (FGF-2), which is highly expressed in developing tissues and malignant cells, regulates cell growth, differentiation, and migration. Five isoforms (18 to approximately 34 kDa) of FGF-2 are derived from alternative initiation codons of a single mRNA. The 18-kDa FGF-2 isoform is released from cells by a nonclassical secretory pathway and regulates gene expression by bin...

Associations of fibroblast growth factor 23 with parameters of phosphate metabolism in incident peritoneal dialysis patients.

dialysis: a meta-analysis of randomized controlled trials. Perit Dial Int 2011; 31:179–88. 2. Paniagua R, Ventura MD, Avila–Díaz M, Cisneros A, Vicenté–Martínez M, Furlong MD, et al. Icodextrin improves metabolic and fluid management in high and high-average transport diabetic patients. Perit Dial Int 2009; 29:422–32. 3. Han SH, Ahn SV, Yun JY, Tranæus A, Han DS. Effects of icodextrin on patien...